Carpal tunnel syndrome is caused by compression of the median nerve, which runs from the forearm into the hand. As the disease progresses and less blood and nutrients flow to the median nerve, pain, numbness, and weakness can develop. The risk of developing carpal tunnel syndrome is not confined to people in a single industry or job, but is especially common in those performing assembly line work -- manufacturing; sewing; finishing; cleaning; and meat, poultry, or fish packing. In addition, women are three times more likely than men to develop the condition.